1,3-dimethyl-1H-indole-2-carbaldehyde → 6-fluoro-1-methyl-3-(methylaminomethyl)-1H-indole

HRID 18263

반응식

HRID 18263 반응식
BrC1C=C[C:5](NCC(OC)=O)=[N:6]C=1.[F:14][C:15]1[CH:23]=[C:22]2[C:18]([C:19]([CH:25]=O)=[CH:20][N:21]2[CH3:24])=[CH:17][CH:16]=1.CN1C2C(=CC=CC=2)C(C)=C1C=O>>[F:14][C:15]1[CH:23]=[C:22]2[C:18]([C:19]([CH2:25][NH:6][CH3:5])=[CH:20][N:21]2[CH3:24])=[CH:17][CH:16]=1

참가 물질

4

반응물 3

HCID 27714681,3-dimethyl-1H-indole-2-carbaldehydeHCID 64981976-Fluoro-1-methyl-1H-indole-3-carbaldehydeHCID 22139049Methyl 2-((5-bromopyridin-2-yl)amino)acetate

생성물 1

HCID 221391586-fluoro-1-methyl-3-(methylaminomethyl)-1H-indole수율 35%

실험 절차

According to the procedure of Preparation 11 (c), except substituting 6-fluoro-1-methyl-1H-indole-3-carboxaldehyde (0.3 g, 1.69 mmole) for the 1,3-dimethyl-1H-indole-2-carboxaldehyde, the title compound (0.11 g, 35%) was prepared as a viscous oil: MS (ES) m/e 193 (M+H)+.

출처 및 근거

ORD 기록
ord-00e4e9be91044d3da0f4b338f7404e08
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07741339B2

연결된 노트

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