Diisopropylethylamine → N-[2-(2(S)-Amino-3-phenyl-propylamino)-1-methyl-6-oxo-4-pyridin-4-yl-1,6-dihydro-pyrimidin-5-yl]-benzamide
반응식
Cl[C:2]1[N:3]([CH3:24])[C:4](=[O:23])[C:5]([NH:14][C:15](=[O:22])[C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[C:6]([C:8]2[CH:13]=[CH:12][N:11]=[CH:10][CH:9]=2)[N:7]=1.[C:25]1([CH2:31][C@H:32]([NH2:35])[CH2:33][NH2:34])[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1.C(N(C(C)C)CC)(C)C>>[NH2:35][C@@H:32]([CH2:31][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)[CH2:33][NH:34][C:2]1[N:3]([CH3:24])[C:4](=[O:23])[C:5]([NH:14][C:15](=[O:22])[C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[C:6]([C:8]2[CH:13]=[CH:12][N:11]=[CH:10][CH:9]=2)[N:7]=1참가 물질
4
실험 절차
N-(2-Chloro-1-methyl-6-oxo-4-pyridin-4-yl-1,6-dihydro-pyrimidin-5-yl)-benzamide (0.07 mmol) was stirred as a solution with 3-phenyl-propane-1,2(S)-diamine (0.15 mmol) and diisopropylethylamine (0.1 mmol) at 0° C. for 2 h. The material was purified on reverse phase HPLC. M+1=455.