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Triphenylphosphine → (2-Propyl-thiazol-5-yl)methyl 4-(5-undecyl-pyrimidin-2-yl)phenyl ether

HRID 1826554
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인쇄 미리보기

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HRID 1826554 반응식
N(C(OCC)=O)=NC(OCC)=O.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.[CH2:32]([C:43]1[CH:44]=[N:45][C:46]([C:49]2[CH:54]=[CH:53][C:52]([OH:55])=[CH:51][CH:50]=2)=[N:47][CH:48]=1)[CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH3:42].[CH2:56]([C:59]1[S:60][C:61]([CH2:64]O)=[CH:62][N:63]=1)[CH2:57][CH3:58]>C1COCC1>[CH2:32]([C:43]1[CH:44]=[N:45][C:46]([C:49]2[CH:50]=[CH:51][C:52]([O:55][CH2:64][C:61]3[S:60][C:59]([CH2:56][CH2:57][CH3:58])=[N:63][CH:62]=3)=[CH:53][CH:54]=2)=[N:47][CH:48]=1)[CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH3:42]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 11776TriphenylphosphineHCID 220568ethyl N-ethoxycarbonyliminocarbamateHCID 22134228(2-Propyl-1,3-thiazol-5-yl)methanolHCID 1356196824-(5-Undecylpyrimidin-2-yl)phenol

생성물 1

HCID 22134209(2-Propyl-thiazol-5-yl)methyl 4-(5-undecyl-pyrimidin-2-yl)phenyl ether

시약·촉매·용매 1

HCID 8028
Tetrahydrofuran
용매

실험 절차

A fully reacted mixture of equimolar amounts of diethyl azodicarboxylate and triphenylphosphine in THF is admixed with equimolar amounts of 4-(5-undecyl-pyrimidin-2-yl)phenol and 2-propylthiazol-5-yl-methanol (prepared by LiAlH4 reduction of methyl 2-propylthiazole-5-carboxylate). The mixture is stirred for 24 h at room temperature and then evaporated to dryness under reduced pressure. Purification by chromatography (silica gel, dichloromethane) and recrystallization affords the target compound.

후처리

  1. customevaporated to dryness under reduced pressure
  2. customPurification
  3. customby chromatography (silica gel, dichloromethane) and recrystallization
  4. customaffords the target compound

출처 및 근거

ORD 기록
ord-1c2d38b5afb54b469b294cf122cf89c2
출처 데이터셋
uspto-grants-2006_05
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07052742B1

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