Ethyl indole-2-carboxylate → 4-fluoro-1-methyl-1H-indole-3-carbaldehyde

반응식

[F:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:3]=1[C:4]([CH:11]=[O:12])=[CH:5][NH:6]2.[CH2:13](OC(C1NC2C(C=1)=CC=CC=2)=O)C>>[F:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:3]=1[C:4]([CH:11]=[O:12])=[CH:5][N:6]2[CH3:13]

참가 물질

반응물 2

HCID 73125Ethyl indole-2-carboxylate

HCID 221390064-Fluoro-1H-indole-3-carbaldehyde

생성물 1

HCID 221389944-fluoro-1-methyl-1H-indole-3-carbaldehyde수율 54%

실험 절차

According to the procedure of Preparation 9 (a), except substituting 4-fluoro-1H-indole-3-carboxaldehyde (0.41 g, 2.5 mmole) for the ethyl-indole-2-carboxylate, the title compound (0.24 g, 54%) was prepared as a viscous oil: MS (ES) m/e 178 (M+H)+.

출처 및 근거

ORD 기록: ord-d928788cda6740eb8747d4e943ef233e
출처 데이터셋: uspto-grants-2010_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07741339B2

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