Malononitrile → HCID 69620621, 화합물

HRID 1826982노트

반응식

HRID 1826982 반응식
[CH:1]([C:3]1[CH:4]=[N:5][CH:6]=[C:7]([CH:10]=1)[C:8]#[N:9])=O.[C:11](#[N:15])[CH2:12][C:13]#[N:14].[OH:16][C:17]1[CH:18]=[CH:19][CH:20]=[C:21]2[C:25]=1[NH:24][CH:23]=[CH:22]2>>[NH2:14][C:13]1[O:16][CH:17]2[C:25]3[C:21](=[CH:20][CH:19]=[C:18]2[CH:1]([C:3]2[CH:4]=[N:5][CH:6]=[C:7]([C:8]#[N:9])[CH:10]=2)[C:12]=1[C:11]#[N:15])[CH:22]=[CH:23][N:24]=3

참가 물질

4

반응물 3

HCID 8010MalononitrileHCID 27376517-HydroxyindoleHCID 129198065-Formylpyridine-3-carbonitrile

생성물 1

HCID 69620621HCID 69620621, 화합물수율 59%

실험 절차

The title compound was prepared from 5-formyl-nicotinonitrile, malononitrile and 7-hydroxyindole by a procedure similar to Example 57 in 59% yield. 1H-NMR (Acetone-d6): 10.54 (brs, 1H), 8.84 (m, J=2.20, 1.90 Hz, 2H), 8.12 (t, J=2.20, 1.90 Hz, 1H), 7.39 (m, J=3.03 Hz, 1H), 7.32 (dd, J=8.00 Hz, 1H), 6.68 (dd, J=8.20 Hz, 1H), 6.51 (m, J=3.03 Hz, 1H), 6.22 (s, 2H), 5.13 (s, 1H).

출처 및 근거

ORD 기록
ord-d1a3abf823da4117bc0f19610c1cbe25
출처 데이터셋
uspto-grants-2006_05
특허 번호
US07053117B2

반응 노트

불러오는 중…