Hydrochloric Acid → 2-Aminomethyl-3-bromo-benzoic acid hydrochloride salt

HRID 1826992노트

반응식

HRID 1826992 반응식
C(OC([NH:8][CH2:9][C:10]1[C:18]([Br:19])=[CH:17][CH:16]=[CH:15][C:11]=1[C:12]([OH:14])=[O:13])=O)(C)(C)C.[ClH:20]>C(OCC)C>[ClH:20].[NH2:8][CH2:9][C:10]1[C:18]([Br:19])=[CH:17][CH:16]=[CH:15][C:11]=1[C:12]([OH:14])=[O:13]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 221368283-Bromo-2-(((tert-butoxycarbonyl)amino)methyl)benzoic acid

생성물 1

HCID 696626982-Aminomethyl-3-bromo-benzoic acid hydrochloride salt수율 13%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

A mixture of 2-(tert-Butoxy carbonylamino-methyl)-3-bromo-benzoic acid (0.188 g, 0.57 mmol) in 2M HCl in diethyl ether (10 ml) was stirred at room temperature for 18 hours. The solvent was removed by evaporation under reduced pressure. The solid was diluted with ethyl acetate/dioxan (1:1) (10 ml) and stirred at room temperature for 1.5 hours. The solid was filtered off and dried to give the title compound (0.02 g, 13%) as a white solid.

후처리

  1. customThe solvent was removed by evaporation under reduced pressure
  2. additionThe solid was diluted with ethyl acetate/dioxan (1:1) (10 ml)
  3. stirringstirred at room temperature for 1.5 hours
  4. filtrationThe solid was filtered off
  5. customdried

출처 및 근거

ORD 기록
ord-b774302d34564f4f959dcda875fed9f7
출처 데이터셋
uspto-grants-2006_05
특허 번호
US07053122B2

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