HCID 10155464, 화합물 → HCID 9858528, 화합물

HRID 1827123노트

반응식

HRID 1827123 반응식
Cl[C:2]1[N:7]=[N:6][C:5]([NH:8][CH2:9][CH:10]2[CH2:15][CH2:14][N:13]([C:16]([O:18][CH2:19][C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)=[O:17])[CH2:12][CH2:11]2)=[CH:4][CH:3]=1.[H][H]>C(O)C.[Ni]>[N:7]1[CH:2]=[CH:3][CH:4]=[C:5]([NH:8][CH2:9][CH:10]2[CH2:15][CH2:14][N:13]([C:16]([O:18][CH2:19][C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)=[O:17])[CH2:12][CH2:11]2)[N:6]=1

참가 물질

5

반응물 2

HCID 10155464HCID 10155464, 화합물HCID 178418361HCID 178418361, 화합물

생성물 1

HCID 9858528HCID 9858528, 화합물

시약·촉매·용매 2

HCID 935Nickel촉매HCID 702Ethanol용매

실험 절차

Benzyl 4-{[(6-chloro-3-pyridazinyl)amino]methyl}-1-piperidinecarboxylate (EXAMPLE 22) (400 mg, 1.11 mmol) was dissolved in absolute ethanol. Raney nickel (65 mg, 1.11 mmol) was then added and the resulting reaction was stirred under 1 atm hydrogen for 18 h. The catalyst was filtered and the filtrate was concentrated under reduced pressure. The resulting clear oil was purified by silica gel chromatography to give the title compound as a clear oil.

후처리

  1. customthe resulting reaction
  2. filtrationThe catalyst was filtered
  3. concentrationthe filtrate was concentrated under reduced pressure
  4. customThe resulting clear oil was purified by silica gel chromatography

출처 및 근거

ORD 기록
ord-ca28e54ade6b4ec6afeb50df6846c162
출처 데이터셋
uspto-grants-2006_05
특허 번호
US07053089B2

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