Sodium Hydroxide → (4s,5r)-2-(2,4-dimethoxyphenyl)-3-(2-nitrophenyl sulfanyl)-4-phenyl-oxazolidine-5-carboxylic acid sodium salt

HRID 1827321노트

반응식

HRID 1827321 반응식
C[O:2][C:3]([CH:5]1[O:9][CH:8]([C:10]2[CH:15]=[CH:14][C:13]([O:16][CH3:17])=[CH:12][C:11]=2[O:18][CH3:19])[N:7]([S:20][C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=2[N+:27]([O-:29])=[O:28])[CH:6]1[C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1)=[O:4].[OH-].[Na+:37]>CO>[CH3:19][O:18][C:11]1[CH:12]=[C:13]([O:16][CH3:17])[CH:14]=[CH:15][C:10]=1[CH:8]1[N:7]([S:20][C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=2[N+:27]([O-:29])=[O:28])[CH:6]([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)[CH:5]([C:3]([O-:4])=[O:2])[O:9]1.[Na+:37]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 86596759HCID 86596759, 화합물

생성물 1

HCID 22137750(4s,5r)-2-(2,4-dimethoxyphenyl)-3-(2-nitrophenyl sulfanyl)-4-phenyl-oxazolidine-5-carboxylic acid sodium salt

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A solution of 5 g of 2-(2,4-dimethoxyphenyl)-3-(2-nitrobenzenesulfenyl)-4-phenyl-5-oxazolidinecarboxylic acid methyl ester in 150 ml of methanol are added with 22 ml of 2% sodium hydroxide. The mixture is refluxed for 1 hour. The solvent is distilled off and the residue is dried at 40° C. under vacuum overnight.

후처리

  1. temperatureThe mixture is refluxed for 1 hour
  2. distillationThe solvent is distilled off
  3. customthe residue is dried at 40° C. under vacuum overnight

출처 및 근거

ORD 기록
ord-ea3abddab4124b789fcef23c82083692
출처 데이터셋
uspto-grants-2006_05
특허 번호
US07053222B2

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