Diethyl Ether → Heptanoic acid, 6-oxo-, methyl ester

HRID 1827673

반응식

HRID 1827673 반응식
[CH2:1](OCC)C.[OH-].[K+].CN(N=O)/C(/N)=N/[N+]([O-])=O.[O:18]=[C:19]([CH3:27])[CH2:20][CH2:21][CH2:22][CH2:23][C:24]([OH:26])=[O:25]>C(Cl)Cl>[CH3:1][O:25][C:24](=[O:26])[CH2:23][CH2:22][CH2:21][CH2:20][C:19](=[O:18])[CH3:27]

참가 물질

6

반응물 4

HCID 3283Diethyl EtherHCID 14797Potassium HydroxideHCID 988106-Oxoheptanoic acidHCID 95620601-Methyl-2-nitro-1-nitrosoguanidine

생성물 1

HCID 288022Heptanoic acid, 6-oxo-, methyl ester

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a rapidly stirred mixture of diethyl ether (175 ml) and 40% KOH (52 ml) at 0° C. was added MNNG (15.4 g, 105 mmol). The mixture was stirred for 10 minutes. The ethereal layer was transferred to a solution of 6-oxo-heptanoic acid 1-1 (5.0 g, 34.68 mmol) and CH2Cl2 at 0° C. The solution was purged with argon for 30 minutes and then concentrated. Flash chromatography (silica, 30–50% EtOAc/hexanes) gave ester 1-2 as a clear oil.

후처리

  1. customThe solution was purged with argon for 30 minutes
  2. concentrationconcentrated

출처 및 근거

ORD 기록
ord-b568aee39c274c39b556d1c29cb3a1d5
출처 데이터셋
uspto-grants-2006_06
특허 번호
US07056909B2

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