Phenothiazine → 9-[(2,4-Diaminothieno[2,3-d]pyrimidin-5-yl)methyl]phenothiazine

HRID 1827712노트

반응식

HRID 1827712 반응식
NC1N=C(N)C2C(CN(C3C=CC=CC=3)C3C=CC=CC=3)=CSC=2N=1.[NH2:26][C:27]1[N:28]=[C:29]([NH2:37])[C:30]2[C:35]([CH3:36])=[CH:34][S:33][C:31]=2[N:32]=1.[CH:38]1[C:51]2[NH:50][C:49]3[C:44](=[CH:45][CH:46]=[CH:47][CH:48]=3)[S:43][C:42]=2[CH:41]=[CH:40][CH:39]=1>>[NH2:26][C:27]1[N:28]=[C:29]([NH2:37])[C:30]2[C:35]([CH2:36][C:48]3[CH:47]=[CH:46][CH:45]=[C:44]4[C:49]=3[NH:50][C:51]3[CH:38]=[CH:39][CH:40]=[CH:41][C:42]=3[S:43]4)=[CH:34][S:33][C:31]=2[N:32]=1

참가 물질

4

반응물 3

HCID 7108PhenothiazineHCID 9906281n-[(2,4-Diaminothieno[2,3-d]pyrimidin-5-yl)methyl]-n,n-diphenylamineHCID 12659534Thieno[2,3-d]pyrimidine-2,4-diamine, 5-methyl-

생성물 1

HCID 220630199-[(2,4-Diaminothieno[2,3-d]pyrimidin-5-yl)methyl]phenothiazine

실험 절차

9-[(2,4-Diaminothieno[2,3-d]pyrimidin-5-yl)methyl]phenothiazine (Formula I: Ar=2,4-diaminothieno[2,3-d]pyrimidin-5-yl; W=CH2; X=N; Z=S; m=n=0) is prepared similarly to N-[(2,4-diaminothieno[2,3-d]pyrimidin-5-yl)methyl]-N,N-diphenylamine as disclosed in Example 11 above by using 2,4-diamino-5-methylthieno[2,3-d]pyrimidine (1.3 g, 7.4 mmol) in Step 1 and phenothiazine (159 mg, 0.8 mmol) in Step 3. The final product and its intermediates can be purified by chromatography.

후처리

  1. customThe final product and its intermediates can be purified by chromatography

출처 및 근거

ORD 기록
ord-fe20ee7f059d456c93876ee6f0635ffe
출처 데이터셋
uspto-grants-2006_06
특허 번호
US07056911B1

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