Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methyl (R)-(+)-2-isocyanato-3-phenylpropionate → (R)-2-(4-Phenoxymethyl-benzyloxycarbonylamino)-3-phenyl-propionic Acid Methyl Ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methyl (R)-(+)-2-isocyanato-3-phenylpropionate | HCID 6558897 | — |
| 반응물 | (4-(Phenoxymethyl)phenyl)methanol | HCID 11333367 | — |
| 촉매 | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| 생성물 | (R)-2-(4-Phenoxymethyl-benzyloxycarbonylamino)-3-phenyl-propionic Acid Methyl Ester | HCID 12990904 | 95.4% |
반응 단계
4-Phenoxymethylphenylmethanol 4 (0.857 g, 4.0 mmol), (R)-2-isocyanato-3-phenyl-propionic acid methyl ester 5 (1.026 g, 5.0 mmol) and 4-dimethylaminopyridine (DMAP) (10 mg) were combined, heated until molten, and stirred for 20 min. Upon cooling, the residue was purified by chromatography to give about 1.6 g of (R)-2-(4-phenoxymethyl-benzyloxycarbonylamino)-3-phenyl-propionic acid methyl ester 6.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07056903B2 |
| 출처 데이터셋 | uspto-grants-2006_06 |
| ORD ID | ord-13b93bb077cb49369b30162400705b29 |
| 출처 메모 | uspto-grants-2006_06 |