N-bromobutanimide → 5-(Bromomethyl)-2-phenylbenzo[d]oxazole
반응식
[CH3:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8]([C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=3)=[N:7][C:6]=2[CH:16]=1.C1C(=O)N([Br:24])C(=O)C1>C(Cl)(Cl)(Cl)Cl>[Br:24][CH2:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8]([C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=3)=[N:7][C:6]=2[CH:16]=1참가 물질
4
실험 절차
5-methyl-2-phenylbenzoxazole 55 (1.23 g, 5.8 mmol) and NBS (1.17 g, 6.5 mmol) were dissolved in carbon tetrachloride (20 ml). The mixture was evacuated and flushed with argon. AIBN (ca. 5 mg) was added and the mixture heated at reflux and irradiated with a sun lamp for 3 hrs. The solvent was evaporated under reduced pressure and the residue purified by chromatography to yield 1.18 g of 5-bromomethyl-2-phenylbenzoxazole 56.
후처리
- customThe mixture was evacuated
- customflushed with argon
- additionAIBN (ca. 5 mg) was added
- temperaturethe mixture heated
- temperatureat reflux
- customirradiated with a sun lamp for 3 hrs
- customThe solvent was evaporated under reduced pressure
- customthe residue purified by chromatography
출처 및 근거
- ORD 기록
- ord-83b48d48847e4f069797f0eb9c3fb400
- 출처 데이터셋
- uspto-grants-2006_06
- 특허 번호
- US07056903B2
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