Methanesulfonyl chloride → Ethyl 2-((diphenylmethylene)amino)-2-(pyrazin-2-yl)acetate

HRID 1827999

반응식

HRID 1827999 반응식
CS(OC[C:7]1[CH:12]=[N:11][CH:10]=[CH:9][N:8]=1)(=O)=O.CS(Cl)(=O)=O.O(CC1C=CC(CO)=CC=1)C1C=CC=CC=1.[Na].[C:35]1([C:41]([C:49]2[CH:54]=[CH:53][CH:52]=[CH:51][CH:50]=2)=[N:42][CH2:43][C:44]([O:46][CH2:47][CH3:48])=[O:45])[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=1>C1COCC1.CN(C=O)C>[N:8]1[CH:9]=[CH:10][N:11]=[CH:12][C:7]=1[CH:43]([C:44]([O:46][CH2:47][CH3:48])=[O:45])[N:42]=[C:41]([C:49]1[CH:54]=[CH:53][CH:52]=[CH:51][CH:50]=1)[C:35]1[CH:36]=[CH:37][CH:38]=[CH:39][CH:40]=1

참가 물질

8

반응물 5

HCID 31297Methanesulfonyl chlorideHCID 319508Ethyl 2-(diphenylmethyleneamino)acetateHCID 5360545SodiumHCID 11333367(4-(Phenoxymethyl)phenyl)methanolHCID 15096999Pyrazin-2-ylmethyl methanesulfonate

생성물 1

HCID 10246971Ethyl 2-((diphenylmethylene)amino)-2-(pyrazin-2-yl)acetate수율 78%

시약·촉매·용매 2

HCID 6228Dimethylformamide용매HCID 8028Tetrahydrofuran용매

실험 절차

A solution of 2-(methanesulfonyloxymethyl)pyrazine (5 mmole), (prepared from 2′-(pyrazin-2-yl)styrene according to the procedure in EP 02257, followed by treatment with methanesulfonyl chloride, according to a procedure in Can. J. Chem. 1999, 77 (4) 463 in 20 ml THF was added dropwise to the sodium salt of ethyl N-(diphenylmethylene)glycinate (5 mmole) in 20 ml DMF cooled in an ice bath. The mixture was allowed to warm to room temperature during 4 hrs. The reaction mixture was partitioned between ether and water. The aqueous layer was separated and reextracted with ether (75 ml). The combined ethereal extracts were washed with brine and dried over MgSO4. Evaporation of the solvent afforded a residue which was chromatographed on silica and eluted with acetone:hexane (1:3) to afford 1.27 g (78%) of ethyl 2-(pyrazin-2-yl)-N-(diphenylmethylene)glycinate.

후처리

  1. temperaturecooled in an ice bath
  2. customThe reaction mixture was partitioned between ether and water
  3. customThe aqueous layer was separated
  4. washThe combined ethereal extracts were washed with brine
  5. dry with materialdried over MgSO4
  6. customEvaporation of the solvent
  7. customafforded a residue which
  8. customwas chromatographed on silica
  9. washeluted with acetone:hexane (1:3)

출처 및 근거

ORD 기록
ord-adc600777d324d9998abf328ccfeb6d9
출처 데이터셋
uspto-grants-2006_06
특허 번호
US07056903B2

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