4-Hydroxybiphenyl → 4-Allyloxybiphenyl

HRID 1828000노트

반응식

HRID 1828000 반응식
[C:1]1([C:7]2[CH:12]=[CH:11][C:10]([OH:13])=[CH:9][CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:14](Br)[CH:15]=[CH2:16].C([O-])([O-])=O.[K+].[K+]>CN(C=O)C.C(OCC)C>[CH2:16]([O:13][C:10]1[CH:9]=[CH:8][C:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)=[CH:12][CH:11]=1)[CH:15]=[CH2:14]

참가 물질

6

반응물 3

HCID 71034-HydroxybiphenylHCID 7841Allyl bromideHCID 11430Potassium Carbonate

생성물 1

HCID 2579864-Allyloxybiphenyl수율 78.9%

시약·촉매·용매 2

HCID 3283Diethyl Ether용매HCID 6228Dimethylformamide용매

실험 절차

4-Phenylphenol 64 (25.5 g, 0.15 mol), allyl bromide (20.0g, 0.165mol) and K2CO3 (41.5 g, 0.15 mol) in 75 ml of dry DMF were stirred at room temperature overnight. The reaction mixture was diluted with 500 ml of diethyl ether and washed with water. The ether layer was washed with brine, dried and concentrated to give a lightly brown solid that was recrystallized from hexane to give 24.9 g of 4-allyloxy-biphenyl 65.

후처리

  1. washwashed with water
  2. washThe ether layer was washed with brine
  3. customdried
  4. concentrationconcentrated
  5. customto give a lightly brown solid that
  6. customwas recrystallized from hexane

출처 및 근거

ORD 기록
ord-c7b2902de8604897b98c8fdb742b0aee
출처 데이터셋
uspto-grants-2006_06
특허 번호
US07056903B2

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