Sodium Bicarbonate → 4-Cyclobutyl-1,3-thiazol-2-amine

HRID 1828445노트

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HRID 1828445 반응식
[NH2:1][C:2]([NH2:4])=[S:3].Br[CH2:6][C:7]([CH:9]1[CH2:12][CH2:11][CH2:10]1)=O.C(=O)([O-])O.[Na+]>C(O)C>[CH:9]1([C:7]2[N:1]=[C:2]([NH2:4])[S:3][CH:6]=2)[CH2:12][CH2:11][CH2:10]1

참가 물질

5

반응물 3

HCID 516892Sodium BicarbonateHCID 2723790ThioureaHCID 110629402-Bromo-1-cyclobutylethan-1-one

생성물 1

HCID 220636344-Cyclobutyl-1,3-thiazol-2-amine

시약·촉매·용매 1

HCID 702Ethanol용매

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온도
100 °C

실험 절차

Thiourea (2.3 g, 30.0 mmol) was dissolved in ethanol (100 ml), added with 2-bromo-1-cyclobutyl-1-ethanone synthesized in the same manner as in Example 1, (E), and then heated to 100° C. The reaction solution was stirred for 1 hour, then returned to room temperature, neutralized with saturated sodium hydrogencarbonate and extracted with chloroform. The collected organic layer was washed with saturated brine, dried over magnesium sulfate and then concentrated under reduced pressure. The title compound was obtained as the residue without purification as a brown oily substance (5.4 g, 100%).

후처리

  1. customsynthesized in the same manner as in Example 1, (E),
  2. customreturned to room temperature
  3. extractionextracted with chloroform
  4. washThe collected organic layer was washed with saturated brine
  5. dry with materialdried over magnesium sulfate
  6. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-e8187ae78d1c4a36845fb1374412f289
출처 데이터셋
uspto-grants-2006_06
특허 번호
US07056917B2

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