Methyl iodide → 3-Methoxy-4-methyl-2-nitropyridine
반응식
[OH:1][C:2]1[C:3]([N+:9]([O-:11])=[O:10])=[N:4][CH:5]=[CH:6][C:7]=1[CH3:8].[C:12](=O)([O-])[O-].[Cs+].[Cs+].CI.C(OCC)(=O)C>CN(C)C=O.CCCCCC>[CH3:12][O:1][C:2]1[C:3]([N+:9]([O-:11])=[O:10])=[N:4][CH:5]=[CH:6][C:7]=1[CH3:8]참가 물질
7
실험 절차
3-Hydroxy-4-methyl-2-nitropyridine (5 g) was dissolved in dimethylformamide (50 ml), added with cesium carbonate (11.6 g) and methyl iodide (13.7 g), and then the mixture was stirred overnight at room temperature. The reaction mixture was added with ethyl acetate and hexane, washed with water and dried over magnesium sulfate, and then the solvent was evaporated under reduced pressure to obtain the title compound (quantitative).
후처리
- washwashed with water
- dry with materialdried over magnesium sulfate
- customthe solvent was evaporated under reduced pressure
출처 및 근거
- ORD 기록
- ord-d8b863c73e0e4ca18bc54436aa86d8dd
- 출처 데이터셋
- uspto-grants-2006_06
- 특허 번호
- US07056917B2
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