Acetic Anhydride → N-(4-methyl-5-nitropyridin-2-yl)acetamide

HRID 1828540

반응식

HRID 1828540 반응식
[CH3:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][N:5]=[C:4]([NH2:11])[CH:3]=1.[C:12](OC(=O)C)(=[O:14])[CH3:13]>O>[CH3:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][N:5]=[C:4]([NH:11][C:12](=[O:14])[CH3:13])[CH:3]=1

참가 물질

4

반응물 2

HCID 7918Acetic AnhydrideHCID 2431652-Amino-4-methyl-5-nitropyridine

생성물 1

HCID 13567013N-(4-methyl-5-nitropyridin-2-yl)acetamide

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
130 °C

실험 절차

4-Methyl-5-nitro-2-pyridinamine (3.69 g, 2.41 mmol) was added with acetic anhydride (10 ml) and stirred at 130° C. for 1.5 hours. The reaction mixture was left stand for cooling, and then added with distilled water (5.4 ml) at 0° C., heated to 130° C., and stirred for 45 minutes. The reaction mixture was left stand for cooling and concentrated, and the deposited crystals were collected by filtration and washed with distilled water to obtain the title compound (4.71 g, quantitative).

후처리

  1. waitThe reaction mixture was left stand
  2. temperaturefor cooling
  3. temperatureheated to 130° C.
  4. stirringstirred for 45 minutes
  5. waitThe reaction mixture was left stand
  6. temperaturefor cooling
  7. concentrationconcentrated
  8. filtrationthe deposited crystals were collected by filtration
  9. washwashed with distilled water

출처 및 근거

ORD 기록
ord-ae1dc800dc2640f1a468cc2b45daad5f
출처 데이터셋
uspto-grants-2006_06
특허 번호
US07056917B2

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