Methyl quinuclidin-3-ylideneacetate hydrochloride → 2-(1-Azabicyclo(2.2.2)octan-3-ylidene)acetic acid hydrochloride

HRID 1828625노트

반응식

HRID 1828625 반응식
[ClH:1].[N:2]12[CH2:9][CH2:8][CH:5]([CH2:6][CH2:7]1)[C:4](=[CH:10][C:11]([O:13]C)=[O:12])[CH2:3]2>Cl>[ClH:1].[N:2]12[CH2:9][CH2:8][CH:5]([CH2:6][CH2:7]1)[C:4](=[CH:10][C:11]([OH:13])=[O:12])[CH2:3]2

참가 물질

3

반응물 1

HCID 67401072Methyl quinuclidin-3-ylideneacetate hydrochloride

생성물 1

HCID 674019582-(1-Azabicyclo(2.2.2)octan-3-ylidene)acetic acid hydrochloride

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

Methyl quinuclidin-3-ylideneacetate hydrochloride (1 g) was heated in concentrated hydrochloric acid (10 ml) at 60° C. for 18 hrs and the solution evaporated to dryness. The residue was kept under vacuum over P2O5 for 3 days to give quinuclidin-3-ylidene acetic acid hydrochloride, 0.91 g (97%) as a white solid; 1H NMR (D2O) inter alia 5.77 (broad s) and 5.86 (broad s) (ca. 1:1, vinyl protons of the two geom. isomers).

후처리

  1. customthe solution evaporated to dryness

출처 및 근거

ORD 기록
ord-0383d9d5988c45968b8c74d7d467b483
출처 데이터셋
uspto-grants-2006_06
특허 번호
USRE039128E1

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