Water → 1-Azabicyclo(2.2.2)octane-4-methanol
반응식
Cl.[N:2]12[CH2:9][CH2:8][C:5]([C:10](O)=[O:11])([CH2:6][CH2:7]1)[CH2:4][CH2:3]2.[H-].[Al+3].[Li+].[H-].[H-].[H-].O.[OH-].[Na+]>O1CCCC1>[N:2]12[CH2:9][CH2:8][C:5]([CH2:10][OH:11])([CH2:6][CH2:7]1)[CH2:4][CH2:3]2참가 물질
6
실험 절차
Quinuclidine-4-carboxylic acid hydrochloride (6.0 g, 0.031 mmoles) in tetrahydrofuran (300 ml) was treated with lithium aluminum hydride (5.0 g, 0.137 mmoles) at ambient temperature for 18 hours. Water (20 ml) and 10% aqueous sodium hydroxide (7.5 ml) was added carefully and the mixture filtered, washing with diethyl ether. The combined filtrates were evaporated to dryness to give the title compound as a white solid 4.04 g, (91%): MS (+ve ion electrospray) m/z 142 (MH+, 100%)
후처리
- filtrationthe mixture filtered
- washwashing with diethyl ether
- customThe combined filtrates were evaporated to dryness
출처 및 근거
- ORD 기록
- ord-d48bc17423494bb691171a0a8e3a27ed
- 출처 데이터셋
- uspto-grants-2006_06
- 특허 번호
- USRE039128E1
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