Chloroacetyl chloride → 4-(2-chloroacetyl)-3,5-dimethyl-1H-pyrrole-2-carbaldehyde

HRID 1828898노트

반응식

HRID 1828898 반응식
[Cl-].[Al+3].[Cl-].[Cl-].[CH3:5][C:6]1[CH:10]=[C:9]([CH3:11])[NH:8][C:7]=1[CH:12]=[O:13].[Cl:14][CH2:15][C:16](Cl)=[O:17]>ClCCCl>[Cl:14][CH2:15][C:16]([C:10]1[C:6]([CH3:5])=[C:7]([CH:12]=[O:13])[NH:8][C:9]=1[CH3:11])=[O:17]

참가 물질

5

반응물 3

HCID 6577Chloroacetyl chlorideHCID 2704653,5-Dimethyl-1H-pyrrole-2-carbaldehydeHCID 6451240Aluminum(III) Chloride

생성물 1

HCID 220598554-(2-chloroacetyl)-3,5-dimethyl-1H-pyrrole-2-carbaldehyde수율 57%

시약·촉매·용매 1

HCID 111,2-Dichloroethane용매

실험 절차

Anhydrous aluminum chloride (42 g, 315 mmol) was added portionwise over 30 min to a room temperature solution of 3,5-dimethylpyrrol-2-carboxaldehyde (5 g, 40 mmol) in 1,2-dichloroethane (50 ml) under nitrogen. After stirring for 15 min, chloroacetyl chloride (17 g, 150 mmol) was added dropwise over 1 h. After addition was complete, the mixture was stirred at room temperature for 16 h. The mixture was poured onto crushed ice and the organic layer separated, dried over anhydrous sodium sulfate, and the solvent removed under reduced pressure. Yield 57%, m.p. 205–09° C. (toluene).

후처리

  1. additionAfter addition
  2. stirringthe mixture was stirred at room temperature for 16 h
  3. additionThe mixture was poured
  4. customonto crushed ice
  5. customthe organic layer separated
  6. dry with materialdried over anhydrous sodium sulfate
  7. customthe solvent removed under reduced pressure

출처 및 근거

ORD 기록
ord-e226a92232d04cdc97ffba1e1b7b32aa
출처 데이터셋
uspto-grants-2006_06
특허 번호
US07060822B1

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