Phosphorus oxychloride → 4-Chloro-2,6-bis(trifluoromethyl)quinoline

HRID 1829160노트

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HRID 1829160 반응식
O[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([C:12]([F:15])([F:14])[F:13])[CH:10]=2)[N:5]=[C:4]([C:16]([F:19])([F:18])[F:17])[CH:3]=1.P(Cl)(Cl)([Cl:22])=O>>[Cl:22][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([C:12]([F:15])([F:14])[F:13])[CH:10]=2)[N:5]=[C:4]([C:16]([F:19])([F:18])[F:17])[CH:3]=1

참가 물질

3

반응물 2

HCID 24813Phosphorus oxychlorideHCID 1785161332,6-Bis(trifluoromethyl)quinolin-4(1H)-one

생성물 1

HCID 6270374-Chloro-2,6-bis(trifluoromethyl)quinoline

실험 절차

4-Hydroxy-2,6-bis(trifluoromethyl)quinoline (1.28 g) was dissolved in phosphorus oxychloride (5.0 mL), and the mixture was stirred at room temperature for 17 hr. The reaction mixture was concentrated under reduced pressure, and saturated aqueous sodium hydrogencarbonate solution was added to the residue. The mixture was extracted with chloroform and concentrated under reduced pressure to give 4-chloro-2,6-bis(trifluoromethyl)quinoline (1.17 g).

후처리

  1. concentrationThe reaction mixture was concentrated under reduced pressure, and saturated aqueous sodium hydrogencarbonate solution
  2. additionwas added to the residue
  3. extractionThe mixture was extracted with chloroform
  4. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-405f0cdc792644d7a54e865f02a624b8
출처 데이터셋
uspto-grants-2006_06
특허 번호
US07060722B2

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