Acetic Anhydride → HCID 22061397, 화합물

HRID 1829177노트

반응식

HRID 1829177 반응식
C(N(CC)CC)C.[C:8](OC(=O)C)(=[O:10])[CH3:9].[NH2:15][CH2:16][CH:17]1[CH2:20][N:19]([C:21]([O:23][C:24]([CH3:27])([CH3:26])[CH3:25])=[O:22])[CH2:18]1>ClCCl>[C:8]([NH:15][CH2:16][CH:17]1[CH2:20][N:19]([C:21]([O:23][C:24]([CH3:27])([CH3:26])[CH3:25])=[O:22])[CH2:18]1)(=[O:10])[CH3:9]

참가 물질

5

반응물 3

HCID 7918Acetic AnhydrideHCID 8471TriethylamineHCID 10679125Tert-butyl 3-(aminomethyl)azetidine-1-carboxylate

생성물 1

HCID 22061397HCID 22061397, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Triethylamine (0.76 ml, 5.45 mmol) and acetic anhydride (0.43 ml, 4.56 mmol) were added to an ice-cooled solution of tert-butyl 3-(aminomethyl)-1-azetidinecarboxylate (J. Med. Chem. 2001; 44(1); 94) (850 mg, 4.56 mmol) in dichloromethane (50 ml), and the reaction stirred for 30 minutes. The solution was washed with water (50 ml), brine (50 ml), dried (MgSO4) and evaporated under reduced pressure. The crude product was purified by column chromatography on silica gel using ethyl acetate as eluant to afford the title compound as a yellow oil.

후처리

  1. washThe solution was washed with water (50 ml), brine (50 ml)
  2. dry with materialdried (MgSO4)
  3. customevaporated under reduced pressure
  4. customThe crude product was purified by column chromatography on silica gel

출처 및 근거

ORD 기록
ord-36e25a305e5142b2b161e92562b5576e
출처 데이터셋
uspto-grants-2006_06
특허 번호
US07060836B2

반응 노트

불러오는 중…