1-Methyl-1H-indole-3-carbaldehyde → HCID 66905063, 화합물

HRID 18297

반응식

HRID 18297 반응식
[Cl:1][C:2]1[N:3]([CH3:13])[C:4]2[C:9]([C:10]=1C=O)=[CH:8][CH:7]=[CH:6][CH:5]=2.[CH3:14][N:15]1C2C(=CC=CC=2)C(C=O)=[CH:16]1>>[Cl:1][C:2]1([CH2:14][NH:15][CH3:16])[CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]1[CH3:13]

참가 물질

3

반응물 2

HCID 878941-Methyl-1H-indole-3-carbaldehydeHCID 3147922-Chloro-1-methyl-1H-indole-3-carbaldehyde

생성물 1

HCID 66905063HCID 66905063, 화합물수율 90%

실험 절차

According to the procedure of Preparation 12, except substituting 2-chloro-1-methyl-1H-indole-3-carboxaldehyde (3.0 g, 15.5 mmole) for the 1-methylindole-3-carboxaldehyde, the title compound (2.91 g, 90%) was prepared as an oil: 1H NMR (400 MHz, CDCl3) δ 7.60 (d, J=7.9 Hz, 1 H), 7.22 (m, 2 H), 7.13 (m, 1 H), 3.92 (s, 2 H), 3.71 (s, 3 H), 2.44 (s, 3 H).

후처리

  1. customAccording to the procedure of Preparation 12

출처 및 근거

ORD 기록
ord-2ae7ea1641db4164a56859ad8f43adb2
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07741339B2

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