Chloroform → HCID 178509715, 화합물

HRID 1829867노트

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HRID 1829867 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:12]2[CH:13]=[N:14][C:15]3[C:20]([CH:21]=2)=[N:19][CH:18]=[CH:17][CH:16]=3)([NH2:11])[CH2:9][NH2:10])=[CH:4][CH:3]=1.CO[C:24]([C:26]1[CH:31]=[CH:30][CH:29]=[C:28]([C:32]#N)[CH:27]=1)=[NH:25].C(Cl)(Cl)Cl>CO>[C:24]([C:26]1[CH:27]=[C:28]([C:32]2[NH:10][CH2:9][C:8]([C:5]3[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=3)([C:12]3[CH:13]=[N:14][C:15]4[C:20]([CH:21]=3)=[N:19][CH:18]=[CH:17][CH:16]=4)[N:11]=2)[CH:29]=[CH:30][CH:31]=1)#[N:25]

참가 물질

5

반응물 3

HCID 6212ChloroformHCID 220548441-(4-Fluorophenyl)-1-(1,5-naphthyridin-3-yl)-1,2-ethanediamineHCID 552656943-Cyano-benzimidic acid methyl ester

생성물 1

HCID 178509715HCID 178509715, 화합물수율 33.8%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of 1-(4-fluorophenyl)-1-(1,5-naphthyridin-3-yl)-1,2-ethanediamine (17 mg) in methanol (1 mL) was added 3-cyanobenzeneimidic acid methyl ester (23 mg), and the mixture was stirred at room temperature for 19 hrs. To the reaction mixture was added chloroform and insolubles were removed by filtration, followed by concentration of the filtrate in vacuo. The residue was purified by preparative thin-layer chromatography (100% ethyl acetate) to give the objective compound (8.0 mg).

후처리

  1. customwere removed by filtration
  2. customThe residue was purified by preparative thin-layer chromatography (100% ethyl acetate)

출처 및 근거

ORD 기록
ord-9fa606034f484356be2bf943a8561e86
출처 데이터셋
uspto-grants-2006_06
특허 번호
US07064142B2

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