Chloroform → HCID 178432502, 화합물

HRID 1829868노트

반응식

HRID 1829868 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:13]2[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=2)([NH2:12])[CH:9]([NH2:11])[CH3:10])=[CH:4][CH:3]=1.CO[C:22]([C:24]1[CH:29]=[CH:28][CH:27]=[C:26]([C:30]#N)[CH:25]=1)=[NH:23].C(Cl)(Cl)Cl>CO>[C:22]([C:24]1[CH:25]=[C:26]([C:30]2[NH:11][CH:9]([CH3:10])[C:8]([C:13]3[CH:14]=[CH:15][C:16]([F:19])=[CH:17][CH:18]=3)([C:5]3[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=3)[N:12]=2)[CH:27]=[CH:28][CH:29]=1)#[N:23]

참가 물질

5

반응물 3

HCID 6212ChloroformHCID 218859191,1-Bis(4-fluorophenyl)-1,2-propanediamineHCID 552656943-Cyano-benzimidic acid methyl ester

생성물 1

HCID 178432502HCID 178432502, 화합물수율 14%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

1,1-bis(4-fluorophenyl)-1,2-propanediamine(50 mg) was dissolved in methanol(1 mL), and to the solution was added 3-cyanobenzeneimidic acid methyl ester (75 mg). The mixture was stirred at room temperature for 24 hrs. After chloroform (5 ml) was added to the reaction mixture, insolubles were removed by filtration. After concentrating the filtrate in vacuo, the obtained residue was purified by silica gel column chromatography (C-300; hexane:ethyl acetate=3:1→1:1) to give the objective compound (10 mg).

후처리

  1. customwere removed by filtration
  2. concentrationAfter concentrating the filtrate in vacuo
  3. customthe obtained residue was purified by silica gel column chromatography (C-300; hexane:ethyl acetate=3:1→1:1)

출처 및 근거

ORD 기록
ord-8bdea606a7c54d29bd2bfefd9a0c9e10
출처 데이터셋
uspto-grants-2006_06
특허 번호
US07064142B2

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