Urea → HCID 178517841, 화합물

HRID 1831050

반응식

HRID 1831050 반응식
[O-]CC.[Na+].[Na].[Cl:6][C:7]1[CH:8]=[C:9]([CH:18]=[CH:19][C:20]=1[Cl:21])[O:10][C:11](=[CH:14]N(C)C)[CH:12]=O.[NH2:22][C:23]([NH2:25])=[O:24]>C(O)C.C(O)(=O)C.O>[Cl:6][C:7]1[CH:8]=[C:9]([CH:18]=[CH:19][C:20]=1[Cl:21])[O:10][C:11]1[CH:14]=[N:22][C:23]([OH:24])=[N:25][CH:12]=1

참가 물질

8

반응물 4

HCID 1176UreaHCID 2723922Sodium ethoxideHCID 5360545SodiumHCID 545558182-(3,4-Dichlorophenoxy)-3-(dimethylamino)prop-2-enal

생성물 1

HCID 178517841HCID 178517841, 화합물수율 17.3%

시약·촉매·용매 3

HCID 176Acetic Acid용매HCID 702Ethanol용매HCID 962Water용매

반응 조건

온도
60 °C

실험 절차

A solution of sodium ethoxide, prepared from sodium (0.95 g, 41.4 mmol), 2-(3,4-dichloro-phenoxy)-3-dimethylamino-propenal (5.38 g, 20.7 mmol) and urea (2.48 g, 41.4 mmol) in ethanol (25 ml) was heated at 60° C. for 4 hours. Water (1 ml) was added and heating was continued for an additional 2 hours. The solution was cooled to room temperature and neutralised with glacial acetic acid. Most of the solvent was removed by evaporation in vacuo. Water was added and the precipitate was isolated by suction, followed by drying in a vacuum oven, yielding the title compound (0.92 g, 17% yield) as a brown solid.

후처리

  1. temperatureheating
  2. customMost of the solvent was removed by evaporation in vacuo
  3. additionWater was added
  4. customthe precipitate was isolated by suction
  5. customby drying in a vacuum oven

출처 및 근거

ORD 기록
ord-833b3decc98144cca4e5174dcc2a9b6b
출처 데이터셋
uspto-grants-2006_06
특허 번호
US07067517B2

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