Stannous Chloride → 4-(2-chloro-4-methoxy-5-methyl-phenyl)-N2-(1-cyclopropyl-propyl)-pyridine-2,3-diamine

HRID 1831583노트

반응식

HRID 1831583 반응식
[Cl:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[C:5]([CH3:10])=[CH:4][C:3]=1[C:11]1[CH:16]=[CH:15][N:14]=[C:13]([NH:17][CH:18]([CH:21]2[CH2:23][CH2:22]2)[CH2:19][CH3:20])[C:12]=1[N+:24]([O-])=O.Cl[Sn]Cl>>[Cl:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[C:5]([CH3:10])=[CH:4][C:3]=1[C:11]1[CH:16]=[CH:15][N:14]=[C:13]([NH:17][CH:18]([CH:21]2[CH2:22][CH2:23]2)[CH2:19][CH3:20])[C:12]=1[NH2:24]

참가 물질

3

반응물 2

HCID 24479Stannous ChlorideHCID 22052097[4-(2-Chloro-4-methoxy-5-methyl-phenyl)-3-nitro-pyridin-2-yl]-(1-cyclopropyl-propyl)-amine

생성물 1

HCID 696581364-(2-chloro-4-methoxy-5-methyl-phenyl)-N2-(1-cyclopropyl-propyl)-pyridine-2,3-diamine수율 98%

실험 절차

[4-(2-Chloro-4-methoxy-5-methyl-phenyl)-3-nitro-pyridin-2-yl]-(1-cyclopropyl-propyl)-amine (90 mg, 0.24 mmol) and SnCl2 (0.13 g, 0.72 mmol) were treated substantially as described in Part D of Example 74a to yield 80 mg (98%) of 4-(2-chloro-4-methoxy-5-methyl-phenyl)-N2-(1-cyclopropyl-propyl)-pyridine-2,3-diamine: MS (EI) m/z 346.22 [(M+H)+, 100].

출처 및 근거

ORD 기록
ord-ba678e07a1014be3bb83b24619517c5d
출처 데이터셋
uspto-grants-2006_06
특허 번호
US07067658B2

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