Dichloroacetic Acid → HCID 54724182, 화합물

HRID 1832016노트

반응식

HRID 1832016 반응식
[F:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][CH:16]=1)[CH2:5][N:6]1[CH:11]=[CH:10][C:9]([OH:12])=[CH:8][C:7]1=[O:13].[I:17]N1C(=O)CCC1=O.ClC(Cl)C(O)=O>C(#N)C>[F:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][CH:16]=1)[CH2:5][N:6]1[CH:11]=[CH:10][C:9]([OH:12])=[C:8]([I:17])[C:7]1=[O:13]

참가 물질

5

반응물 3

HCID 6597Dichloroacetic AcidHCID 120273N-IodosuccinimideHCID 54724162HCID 54724162, 화합물

생성물 1

HCID 54724182HCID 54724182, 화합물

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

To a mixture of 1-(3-fluorobenzyl)-4-hydroxypyridin-2(1H)-one (1.1 g, 5 mmol) in acetonitrile (15 mL) was added N-iodosuccinimide (1.1 g, 5.5 mmol) along with a ca. amount of dichloroacetic acid (0.1 mL). The reaction mixture stirred at room temperature for 1 hour under nitrogen. The mixture was chilled in an ice bath and filtered cold with fresh MeCl2. The beige solid was dried to afford the desired iodinated intermediate (1.21 g, 69%). ES-LRMS m/z 346.

후처리

  1. temperatureThe mixture was chilled in an ice bath
  2. filtrationfiltered cold with fresh MeCl2
  3. customThe beige solid was dried
  4. customto afford the

출처 및 근거

ORD 기록
ord-ee33e594a3b545c2a5d89d6c8aeb8ae8
출처 데이터셋
uspto-grants-2006_06
특허 번호
US07067540B2

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