Hydrochloric Acid → Acetamide, N-[3-(4-piperidinyl)phenyl]-

HRID 1832140노트

반응식

HRID 1832140 반응식
Cl.[C:2]([NH:5][C:6]1[CH:7]=[C:8]([CH:12]2[CH2:17][CH2:16][N:15](C(OC(C)(C)C)=O)[CH2:14][CH2:13]2)[CH:9]=[CH:10][CH:11]=1)(=[O:4])[CH3:3]>O1CCOCC1.ClCCl>[NH:15]1[CH2:16][CH2:17][CH:12]([C:8]2[CH:7]=[C:6]([NH:5][C:2](=[O:4])[CH3:3])[CH:11]=[CH:10][CH:9]=2)[CH2:13][CH2:14]1

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 22049422Tert-butyl 4-[3-(acetylamino)phenyl]-1-piperidinecarboxylate

생성물 1

HCID 22048943Acetamide, N-[3-(4-piperidinyl)phenyl]-수율 121.6%

시약·촉매·용매 2

HCID 6344Dichloromethane용매HCID 312751,4-Dioxane용매

실험 절차

A solution of HCl in dioxane (4N, 5 mL) was added to tert-butyl 4-[3-(acetylamino)phenyl]-1-piperidinecarboxylate (660 mg) in dry dichloromethane (15 mL). The reaction mixture was stirred at room temperature overnight and concentrated in vacuo, giving the desired product (550 mg): mp 102–104° C.; 1H NMR (CDCl3) δ 2.02 (d, J=13.2 Hz, 2H), 2.11–2.45 (m, 5H), 2.67–2.77 (m, 1H), 3.00–3.10 (m, 2H), 3.51 (d, J=10.5 Hz, 2H), 6.94 (d, J=7.5 Hz, 1H), 7.20–7.46 (m, 3H), 7.60 (s, 1H); Anal. Calcd. For C13H19N2OCl+0.86 CH2Cl2: C, 50.78; H, 6.37; N, 8.55. Found: C, 50.80; H, 7.55; N, 7.01.

후처리

  1. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-1147baa10fe945a19dfea409e817be01
출처 데이터셋
uspto-grants-2006_06
특허 번호
US07067534B1

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