6-Butoxy-7-methoxy-1-(3-methoxy-benzyl)-1,2-dihydro-isoquinoline-4-carbaldehyde → 6-Butoxy-7-methoxy-1-(3-methoxy-benzyl)-isoquinoline-4-carbaldehyde

HRID 1833150노트

반응식

HRID 1833150 반응식
[CH2:1]([O:5][C:6]1[CH:7]=[C:8]2[C:13](=[CH:14][C:15]=1[O:16][CH3:17])[CH:12]([CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[C:21]([O:25][CH3:26])[CH:20]=1)[NH:11][CH:10]=[C:9]2[CH:27]=[O:28])[CH2:2][CH2:3][CH3:4]>C(Cl)(Cl)Cl.[O-2].[Mn+4].[O-2]>[CH2:1]([O:5][C:6]1[CH:7]=[C:8]2[C:13](=[CH:14][C:15]=1[O:16][CH3:17])[C:12]([CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[C:21]([O:25][CH3:26])[CH:20]=1)=[N:11][CH:10]=[C:9]2[CH:27]=[O:28])[CH2:2][CH2:3][CH3:4]

참가 물질

4

반응물 1

HCID 220482446-Butoxy-7-methoxy-1-(3-methoxy-benzyl)-1,2-dihydro-isoquinoline-4-carbaldehyde

생성물 1

HCID 220482946-Butoxy-7-methoxy-1-(3-methoxy-benzyl)-isoquinoline-4-carbaldehyde수율 99.4%

시약·촉매·용매 2

HCID 178418406HCID 178418406, 화합물촉매HCID 6212Chloroform용매

실험 절차

To a stirred solution of 6-butoxy-7-methoxy-1-(3-methoxy-benzyl)-1,2-dihydro-isoquinoline-4-carbaldehyde (200 mg, 0.53 mmol) in chloroform (6 mL) was added manganese (IV) oxide (536 mg, 5.34 mmol). The reaction mixture was stirred at room temperature for 15 hrs, filtered through a Celite® pad, and washed with chloroform. The filtrate was concentrated in vacuo to afford 6-butoxy-7-methoxy-1-(3-methoxy-benzyl)-isoquinoline-4-carbaldehyde (200 mg, 99% yield). The crude product was without further purification.

후처리

  1. filtrationfiltered through a Celite® pad
  2. washwashed with chloroform
  3. concentrationThe filtrate was concentrated in vacuo

출처 및 근거

ORD 기록
ord-3c570257739e4920be79cdda374406db
출처 데이터셋
uspto-grants-2006_06
특허 번호
US07067529B2

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