Acetic Anhydride → 6-(3-acetoxy-propoxy)-7-methoxy-1-(3-methoxy-benzyl)-1H-isoquinoline-2-carboxylic acid ethyl ester

HRID 1833167노트

반응식

HRID 1833167 반응식
[CH2:1]([O:3][C:4]([N:6]1[CH:15]=[CH:14][C:13]2[C:8](=[CH:9][C:10]([O:21][CH3:22])=[C:11]([O:16][CH2:17][CH2:18][CH2:19][OH:20])[CH:12]=2)[CH:7]1[CH2:23][C:24]1[CH:29]=[CH:28][CH:27]=[C:26]([O:30][CH3:31])[CH:25]=1)=[O:5])[CH3:2].[C:32](OC(=O)C)(=[O:34])[CH3:33]>N1C=CC=CC=1>[CH2:1]([O:3][C:4]([N:6]1[CH:15]=[CH:14][C:13]2[C:8](=[CH:9][C:10]([O:21][CH3:22])=[C:11]([O:16][CH2:17][CH2:18][CH2:19][O:20][C:32](=[O:34])[CH3:33])[CH:12]=2)[CH:7]1[CH2:23][C:24]1[CH:29]=[CH:28][CH:27]=[C:26]([O:30][CH3:31])[CH:25]=1)=[O:5])[CH3:2]

참가 물질

4

반응물 2

HCID 7918Acetic AnhydrideHCID 69558143HCID 69558143, 화합물

생성물 1

HCID 695582746-(3-acetoxy-propoxy)-7-methoxy-1-(3-methoxy-benzyl)-1H-isoquinoline-2-carboxylic acid ethyl ester수율 99%

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

To a stirred solution of 6-(3-hydroxy-propoxy)-7-methoxy-1-(3-methoxy-benzyl)-1H isoquinoline-2-carboxylic acid ethyl ester (130 mg, 0.30 mmol) in pyridine (2 μL) was added acetic anhydride (1 mL). The reaction mixture was stirred at room temperature for 15 hrs. The solvent was evaporated and toluene was added to remove pyridine completely. The crude product 6-(3-acetoxy-propoxy)-7-methoxy-1-(3-methoxy-benzyl)-1H-isoquinoline-2-carboxylic acid ethyl ester (142, 99% yield) was used without further purification.

후처리

  1. customThe solvent was evaporated
  2. additiontoluene was added
  3. customto remove pyridine completely

출처 및 근거

ORD 기록
ord-3da3b78c8c5c49318bf52d87048a0ad6
출처 데이터셋
uspto-grants-2006_06
특허 번호
US07067529B2

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