Phosphorus oxychloride → Ethyl 7-[5-(p-fluorophenyl)-2-pentyl]-5-hydroxy-4-methylcoumarin-3-propionate

HRID 1833423

반응식

[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10][CH:11]([C:13]2[CH:14]=[C:15]([OH:20])[CH:16]=[C:17]([CH:19]=2)[OH:18])[CH3:12])=[CH:4][CH:3]=1.[C:21]([CH:24]([CH2:30][CH2:31][C:32]([O:34][CH2:35][CH3:36])=[O:33])[C:25](OCC)=[O:26])(=O)[CH3:22].P(Cl)(Cl)(Cl)=O>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10][CH:11]([C:13]2[CH:14]=[C:15]3[C:16]([C:21]([CH3:22])=[C:24]([CH2:30][CH2:31][C:32]([O:34][CH2:35][CH3:36])=[O:33])[C:25](=[O:26])[O:20]3)=[C:17]([OH:18])[CH:19]=2)[CH3:12])=[CH:4][CH:3]=1

참가 물질

반응물 3

HCID 24813Phosphorus oxychloride

HCID 73915Diethyl 2-acetylglutarate

HCID 202879045-[5-(4-Fluorophenyl)pentan-2-yl]benzene-1,3-diol

생성물 1

HCID 22765002Ethyl 7-[5-(p-fluorophenyl)-2-pentyl]-5-hydroxy-4-methylcoumarin-3-propionate

실험 절차

Ethyl 7-[5-(p-fluorophenyl)-2-pentyl]-5-hydroxy-4-methylcoumarin-3-propionate is prepared by reaction of 5-[5-(p-fluorophenyl)-2-pentyl]resorcinol, diethyl α-acetylglutarate, and phosphorus oxychloride according to the method of Example 1.

출처 및 근거

ORD 기록: ord-a4242383c0c1408198f8124990b68f9e
출처 데이터셋: uspto-grants-1978_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04066667

연결된 노트

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