Dimethylformamide → 2-[(2,6-Dichloropyridin-3-yl)oxy]propanoyl chloride

HRID 1833830노트

반응식

HRID 1833830 반응식
[Cl:1][C:2]1[C:7]([O:8][CH:9]([CH3:13])[C:10](O)=[O:11])=[CH:6][CH:5]=[C:4]([Cl:14])[N:3]=1.CN(C)C=O.S(Cl)([Cl:22])=O>C(Cl)(Cl)Cl>[Cl:1][C:2]1[C:7]([O:8][CH:9]([CH3:13])[C:10]([Cl:22])=[O:11])=[CH:6][CH:5]=[C:4]([Cl:14])[N:3]=1

참가 물질

5

반응물 3

HCID 6228DimethylformamideHCID 24386Thionyl ChlorideHCID 129061732-[(2,6-Dichloropyridin-3-yl)oxy]propanoic acid

생성물 1

HCID 129061742-[(2,6-Dichloropyridin-3-yl)oxy]propanoyl chloride

시약·촉매·용매 1

HCID 6212Chloroform용매2회

실험 절차

23.6 g (0.1 mole) of 2-[(2,6-dichloro-3-pyridyl)oxy]-propionic acid, 150 ml of chloroform and 1.5 ml of dimethylformamide are heated with stirring to 55°, and in the course of 1 hour a solution of 18 g (0.15 mole) of thionyl chloride in 40 ml of chloroform is added dropwise. The reaction mixture is subsequently refluxed for 16 hours and is afterwards concentrated in vacuo. The product obtained is used directly for further reactions.

후처리

  1. temperatureThe reaction mixture is subsequently refluxed for 16 hours
  2. concentrationis afterwards concentrated in vacuo
  3. customThe product obtained

출처 및 근거

ORD 기록
ord-44bb6621ad28421f8c8cf23cd617d584
출처 데이터셋
uspto-grants-1978_01
특허 번호
US04067725

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