Magnesium monoxide → 3-Benzylpyridazine
반응식
Cl[CH:2]([C:9]1[N:10]=[N:11][CH:12]=[CH:13][CH:14]=1)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[H][H].[O-2].[Mg+2]>C(O)C.[Pd]>[CH2:2]([C:9]1[N:10]=[N:11][CH:12]=[CH:13][CH:14]=1)[C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1참가 물질
6
실험 절차
A solution of (±) 3-α-chlorobenzylpyridazine (2.05 g.) in ethanol (50 ml.) was treated with hydrogen, in the presence of magnesium oxide (0.4 g.) and palladium on charcoal (5% Pd; 0.2 g.), for 1 hour at ambient temperature and normal atmospheric pressure. The solution was then filtered and the filtrate was evaporated to dryness. The residue was dissolved in hot chloroform (100 ml.), cooled, washed with water (50 ml.), dried over magnesium sulphate and evaporated to give 3-benzylpyridazine (1.6 g.), m.p. 61°-64° C., in the form of a light brown coloured solid.
후처리
- filtrationThe solution was then filtered
- customthe filtrate was evaporated to dryness
- dissolutionThe residue was dissolved in hot chloroform (100 ml.)
- temperaturecooled
- washwashed with water (50 ml.)
- dry with materialdried over magnesium sulphate
- customevaporated
출처 및 근거
- ORD 기록
- ord-ab703a07c09346e8ab24ce79bed21700
- 출처 데이터셋
- uspto-grants-1978_01
- 특허 번호
- US04067723
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