Benzaldehyde → (+/-) 3-alpha-Hydroxybenzylpyridazine
반응식
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]([OH:9])=O)[N:2]=1.C(=O)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>CC1C=CC(C(C)C)=CC=1>[OH:9][CH:7]([C:3]1[N:2]=[N:1][CH:6]=[CH:5][CH:4]=1)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1참가 물질
4
반응 조건
- 온도
- 135 °C
실험 절차
Pyridazine-3-carboxylic acid [prepared as described by Leanza, Becker and Rogers, J.A.C.S., 75, 4086 (1953); 18.6 g.] was mixed with benzaldehyde (44 g.) and p-cymene (360 ml.) and decarboxylated by heating for 3 hours at 135° C. The hot solution was then filtered, cooled and the precipitate collected to give (±) 3-α-hydroxybenzylpyridazine (5.2 g.), m.p. 130°-135° C., in the form of fawn coloured needles.
후처리
- filtrationThe hot solution was then filtered
- temperaturecooled
- customthe precipitate collected
출처 및 근거
- ORD 기록
- ord-e92ba4ad06404f609a6584063ce73fb4
- 출처 데이터셋
- uspto-grants-1978_01
- 특허 번호
- US04067723
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