Benzaldehyde → (+/-) 3-alpha-Hydroxybenzylpyridazine

HRID 1833843

반응식

HRID 1833843 반응식
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]([OH:9])=O)[N:2]=1.C(=O)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>CC1C=CC(C(C)C)=CC=1>[OH:9][CH:7]([C:3]1[N:2]=[N:1][CH:6]=[CH:5][CH:4]=1)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

참가 물질

4

반응물 2

HCID 240BenzaldehydeHCID 269369Pyridazine-3-carboxylic acid

생성물 1

HCID 10397539(+/-) 3-alpha-Hydroxybenzylpyridazine수율 18.6%

시약·촉매·용매 1

HCID 7463P-Cymene용매

반응 조건

온도
135 °C

실험 절차

Pyridazine-3-carboxylic acid [prepared as described by Leanza, Becker and Rogers, J.A.C.S., 75, 4086 (1953); 18.6 g.] was mixed with benzaldehyde (44 g.) and p-cymene (360 ml.) and decarboxylated by heating for 3 hours at 135° C. The hot solution was then filtered, cooled and the precipitate collected to give (±) 3-α-hydroxybenzylpyridazine (5.2 g.), m.p. 130°-135° C., in the form of fawn coloured needles.

후처리

  1. filtrationThe hot solution was then filtered
  2. temperaturecooled
  3. customthe precipitate collected

출처 및 근거

ORD 기록
ord-e92ba4ad06404f609a6584063ce73fb4
출처 데이터셋
uspto-grants-1978_01
특허 번호
US04067723

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