Dichloromethane → 2-Pyrrolidinone, 3-chloro-4-(chloromethyl)-1-(phenylmethyl)-

HRID 1834109노트

반응식

HRID 1834109 반응식
[CH2:1]([N:4]([CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[C:5](=[O:9])[CH:6](Cl)[Cl:7])[CH:2]=[CH2:3].COCCOCCOC.N1CCCC1=O.C(Cl)[Cl:33]>>[CH2:10]([N:4]1[CH2:1][CH:2]([CH2:3][Cl:33])[CH:6]([Cl:7])[C:5]1=[O:9])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

참가 물질

5

반응물 4

HCID 6344DichloromethaneHCID 8150DiglymeHCID 120252-PyrrolidoneHCID 10083827Acetamide, 2,2-dichloro-N-(phenylmethyl)-N-2-propenyl-

생성물 1

HCID 118212562-Pyrrolidinone, 3-chloro-4-(chloromethyl)-1-(phenylmethyl)-

실험 절차

Eleven and one-tenth grams of N-allyl-N-benzyl dichloroacetamide was dissolved in 12 ml. of diglyme and 1 g. of anhydrous ferrous chloride added. The mixture was heated at reflux under nitrogen until conversion to the pyrrolidinone was complete as indicated by GLPC. The mixture was diluted with methylene chloride, washed with 5 per cent hydrochloric acid, separated, dried over anhydrous magnesium sulfate, treated with activated carbon and Florisil and stripped under vacuum. Yield was 6 g. of the title compound, nD30 1.5387.

후처리

  1. temperatureThe mixture was heated
  2. washwashed with 5 per cent hydrochloric acid
  3. customseparated
  4. dry with materialdried over anhydrous magnesium sulfate
  5. additiontreated with activated carbon and Florisil

출처 및 근거

ORD 기록
ord-6ec93fadb1a84c53ada798b7bce2a59a
출처 데이터셋
uspto-grants-1978_01
특허 번호
US04069038

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