Water → Phenyl 4-chloro-3-nitrobenzenesulfonate

HRID 1834218

반응식

HRID 1834218 반응식
[N+:1]([C:4]1[CH:5]=[C:6]([S:11](Cl)(=[O:13])=[O:12])[CH:7]=[CH:8][C:9]=1[Cl:10])([O-:3])=[O:2].[C:15]1([OH:21])[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1.C(N(CC)CC)C.O>CC(C)=O>[C:15]1([O:21][S:11]([C:6]2[CH:7]=[CH:8][C:9]([Cl:10])=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=2)(=[O:12])=[O:13])[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 996PhenolHCID 7323Benzenesulfonyl chloride, 4-chloro-3-nitro-HCID 8471Triethylamine

생성물 1

HCID 266121Phenyl 4-chloro-3-nitrobenzenesulfonate수율 86.4%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

3-Nitro-4-Chloro-benzene-sulfonic acid-phenylester was obtained by mixing 51 g of 3-nitro-4-chloro-benzene-sulfonic acid-chloride with 18.8 g of phenol in 120 ml of acetone, and by adding 28 ml of triethylamine dropwise, while cooling, at a temperature not exceeding 10° C. The mixture was continued to be stirred for several hours at room temperature, and then water was added, in which process an oil was separated which was extracted with ether. After recrystallization of the residue from methanol, 54 g of 3-nitro-4-chloro-benzene-sulfonic acid-phenylester were obtained, which had a melting point of 71° C.

후처리

  1. temperaturewhile cooling, at a temperature not
  2. customexceeding 10° C
  3. customwas separated which
  4. extractionwas extracted with ether
  5. customAfter recrystallization of the residue from methanol

출처 및 근거

ORD 기록
ord-68f9f87caa824dce93a2d5dd5a4266ed
출처 데이터셋
uspto-grants-1978_01
특허 번호
US04069325

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