4-Chlorobenzenesulfonyl chloride → Benzenesulfonamide, 4-chloro-N-(2-hydroxyethyl)-N-methyl-

HRID 1834347노트

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HRID 1834347 반응식
[CH3:1][NH:2][CH2:3][CH2:4][OH:5].[Cl:6][C:7]1[CH:12]=[CH:11][C:10]([S:13](Cl)(=[O:15])=[O:14])=[CH:9][CH:8]=1>O1CCCC1>[CH3:1][N:2]([CH2:3][CH2:4][OH:5])[S:13]([C:10]1[CH:11]=[CH:12][C:7]([Cl:6])=[CH:8][CH:9]=1)(=[O:15])=[O:14]

참가 물질

4

반응물 2

HCID 73984-Chlorobenzenesulfonyl chlorideHCID 80162-(Methylamino)ethanol

생성물 1

HCID 108691Benzenesulfonamide, 4-chloro-N-(2-hydroxyethyl)-N-methyl-

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

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온도
50 °C

실험 절차

To 20 parts of tetrahydrofuran is added 3.9 parts of N-methyl-ethanolamine. To this solution, 10 parts of tetrahydrofuran containing 5 parts of p-chlorobenzenesulfonyl chloride is added with stirring. After completion of the addition, the resultant mixture is stirred as it is for a while, and then heated for about 1 hour on a water bath at 50° C to terminate the reaction. Then, the salt is removed by filtration, and the filtrate is freed from the solvent, whereby an oily substance is obtained. This oily substance is subjected to distillation under reduced pressure to obtain 4.2 parts of a distillate, b.p. 180° C/0.5 mmHg.

후처리

  1. additionAfter completion of the addition
  2. customto terminate
  3. customthe reaction
  4. customThen, the salt is removed by filtration
  5. customis obtained
  6. distillationThis oily substance is subjected to distillation under reduced pressure
  7. customto obtain 4.2 parts of a distillate, b.p. 180° C/0.5 mmHg

출처 및 근거

ORD 기록
ord-06267d990e584ad2911a17af6d3186b2
출처 데이터셋
uspto-grants-1978_01
특허 번호
US04070176

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