Propanal → 2,4-Dimethyl-3-acetyl-5-n-Propyl-pyrrole

HRID 1834410노트

반응식

HRID 1834410 반응식
[CH3:1][C:2]1[NH:3][CH:4]=[C:5]([CH3:10])[C:6]=1[C:7](=[O:9])[CH3:8].I.[CH:12](=O)[CH2:13][CH3:14].CC1NC(C(OCC)=O)=C(C)C=1C>CCOCC.C(O)(=O)C>[CH3:1][C:2]1[NH:3][C:4]([CH2:12][CH2:13][CH3:14])=[C:5]([CH3:10])[C:6]=1[C:7](=[O:9])[CH3:8]

참가 물질

7

반응물 4

HCID 527PropanalHCID 15163Ketone, 2,4-dimethylpyrrol-3-yl methylHCID 24841Hydrogen iodideHCID 137479Ethyl 3,4,5-trimethyl-1H-pyrrole-2-carboxylate

생성물 1

HCID 203732052,4-Dimethyl-3-acetyl-5-n-Propyl-pyrrole수율 59%

시약·촉매·용매 2

HCID 176Acetic Acid용매HCID 3283Diethyl Ether용매

실험 절차

2,4-Dimethyl-3-acetyl-pyrrole (1.02 g), acetic acid (15 ml), aqueous hydriodic acid (25ml) and propionaldehyde (1.74g), were stirred at 25° C. three hours under nitrogen. The work up was the same as that of 2,3,4-trimethyl-5-carbethoxy-pyrrole in Example 4 except that 2 × 50 ml ether were used. Recrystallization from benzene gave the product 0.786 g (59%) m.p. 157°-158°C.

후처리

  1. customRecrystallization from benzene

출처 및 근거

ORD 기록
ord-d080107f1784485ba4badc191f6a9788
출처 데이터셋
uspto-grants-1978_01
특허 번호
US04070366

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