Glycidol → N-(2,3-dihydroxypropyl)-N-(2-hydroxyoctyl) amine
반응식
[OH:1][CH:2]([CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH3:10])[CH2:3][NH2:4].[CH2:11]1[O:13][CH:12]1[CH2:14][OH:15]>C1(C)C=CC=CC=1>[OH:13][CH:12]([CH2:14][OH:15])[CH2:11][NH:4][CH2:3][CH:2]([OH:1])[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH3:10]참가 물질
4
실험 절차
108.8 grams of 2-hydroxyoctyl amine were dissolved in 500 ml of toluene, heated to reflux, treated within 10 minutes under stirring with 18.5 grams of glycidol and held at reflux for 2 hours. Subsequently, the solvent was drawn off and the excess amine distilled off in a vacuum. There were obtained as a residue 49.5 grams (90.5% of theory) of N-(2,3-dihydroxypropyl)-N-(2-hydroxyoctyl) amine which after recrystallization from ethylacetate gave colorless crystals having a melting point of 85°-90° C.
후처리
- temperatureheated
- temperatureto reflux
- additiontreated within 10 minutes
- temperatureat reflux for 2 hours
- distillationthe excess amine distilled off in a vacuum
출처 및 근거
- ORD 기록
- ord-30de76e44e1644aa9c53990c0590c805
- 출처 데이터셋
- uspto-grants-1978_01
- 특허 번호
- US04070531
반응 노트
불러오는 중…