N-(2-ethylthioethyl)-glycine tert-butyl ester → HCID 178477443, 화합물

HRID 1834875노트

반응식

HRID 1834875 반응식
[C:1]([O:5][C:6](=[O:14])[CH2:7][NH:8][CH2:9][CH2:10][S:11][CH2:12][CH3:13])([CH3:4])([CH3:3])[CH3:2].[N:15]#[N:16].Cl.[CH3:18][O:19][C:20]1[CH:21]=[C:22]2[C:27](=[CH:28][C:29]=1[O:30][CH3:31])[CH:26]=[C:25]([S:32]([NH:35][C@H:36]([C:44](Cl)=[O:45])[CH2:37][CH2:38][CH2:39][NH:40][C:41](=[NH:43])[NH2:42])(=[O:34])=[O:33])[CH:24]=[CH:23]2>C(Cl)(Cl)Cl>[N:15]#[N:16].[C:1]([O:5][C:6](=[O:14])[CH2:7][N:8]([C:44](=[O:45])[C@H:36]([CH2:37][CH2:38][CH2:39][NH:40][C:41](=[NH:42])[NH2:43])[NH:35][S:32]([C:25]1[CH:24]=[CH:23][C:22]2[C:27](=[CH:28][C:29]([O:30][CH3:31])=[C:20]([O:19][CH3:18])[CH:21]=2)[CH:26]=1)(=[O:34])=[O:33])[CH2:9][CH2:10][S:11][CH2:12][CH3:13])([CH3:4])([CH3:3])[CH3:2]

참가 물질

4

반응물 2

HCID 20372345N-(2-ethylthioethyl)-glycine tert-butyl esterHCID 178486632HCID 178486632, 화합물

생성물 1

HCID 178477443HCID 178477443, 화합물

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

To a stirred solution of 4.80 g of N-(2-ethylthioethyl)-glycine tert-butyl ester in 40 ml of chloroform was carefully added N2 -(6,7-dimethoxy-2-naphthalenesulfonyl)-L-arginyl chloride hydrochloride obtained above. The reaction mixture was allowed to stand at room temperature overnight. The reaction mixture was washed twice with 20 ml of saturated sodium chloride solution and evaporated to dryness. The residue was triturated with a small amount of water to give a powder. This was collected by filtration and reprecipitated with ethanol-diethyl ether to give 5.00 g of N2 -(6,7-dimethoxy-2-naphthalenesulfonyl)-L-arginyl-N-(2-ethylthioethyl)glycine tert-butyl ester.

후처리

  1. customobtained above
  2. washThe reaction mixture was washed twice with 20 ml of saturated sodium chloride solution
  3. customevaporated to dryness
  4. customThe residue was triturated with a small amount of water
  5. customto give a powder
  6. filtrationThis was collected by filtration
  7. customreprecipitated with ethanol-diethyl ether

출처 및 근거

ORD 기록
ord-071703dfd5f84a618b37b54da9ef0cd9
출처 데이터셋
uspto-grants-1978_01
특허 번호
US04071621

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