Hydrogen Bromide → 1-Methyl-3-(5H-pyrrolo[2,3-b]pyrazin-6-yl)-1H-indol-5-ol

HRID 1835182노트

반응식

HRID 1835182 반응식
C[O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[N:8]([CH3:12])[CH:7]=[C:6]2[C:13]1[NH:21][C:16]2=[N:17][CH:18]=[CH:19][N:20]=[C:15]2[CH:14]=1.Br.C(=O)(O)[O-].[Na+]>C(O)(=O)C>[CH3:12][N:8]1[C:9]2[C:5](=[CH:4][C:3]([OH:2])=[CH:11][CH:10]=2)[C:6]([C:13]2[NH:21][C:16]3=[N:17][CH:18]=[CH:19][N:20]=[C:15]3[CH:14]=2)=[CH:7]1

참가 물질

5

반응물 3

HCID 260Hydrogen BromideHCID 516892Sodium BicarbonateHCID 98604486-(5-methoxy-1-methyl-1H-indol-3-yl)-5H-pyrrolo[2,3-b]pyrazine

생성물 1

HCID 224772321-Methyl-3-(5H-pyrrolo[2,3-b]pyrazin-6-yl)-1H-indol-5-ol수율 94.8%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

A mixture of 6-(5-methoxy-1-methyl-1H-indol-3-yl)-5H-pyrrolo[2,3-b]pyrazine [200 mg, Example 1(a)] hydrobromic acid (48%, 500 μl) and glacial acetic acid (3 mL) was heated under reflux for 14 hours. After cooling the mixture was neutralised by addition of saturated sodium bicarbonate solution. The resulting dark solid was filtered and then dried to give the title compound (180 mg) as a black solid, m.p. 289-290° C. MS: 264 (MH+).

후처리

  1. temperaturewas heated
  2. temperatureunder reflux for 14 hours
  3. temperatureAfter cooling the mixture
  4. filtrationThe resulting dark solid was filtered
  5. customdried

출처 및 근거

ORD 기록
ord-fa933a135fd449209b494e29d6e5b87e
출처 데이터셋
uspto-grants-2004_08
특허 번호
US06770643B2

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