Sodium Chloride → Indoxyl

HRID 1835618노트

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HRID 1835618 반응식
CC([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6]([O:13]C(C)=O)=[CH:5]1)=O.[OH-].[Na+].O.C(O)(=O)CC(CC(O)=O)(C(O)=O)O.[Na+].[Cl-]>O>[OH:13][C:6]1[C:7]2[C:12](=[CH:11][CH:10]=[CH:9][CH:8]=2)[NH:4][CH:5]=1

참가 물질

6

반응물 4

HCID 5234Sodium ChlorideHCID 14798Sodium HydroxideHCID 222302-Hydroxy-1,2,3-propanetricarboxylic acid hydrate (1:1)HCID 5836021-Acetyl-1H-indol-3-yl acetate

생성물 1

HCID 50591Indoxyl수율 80.6%

시약·촉매·용매 1

HCID 962Water용매2회

반응 조건

온도
85 °C

실험 절차

Indoxyl 1,3-diacetate (Sigma Chemical Co., St. Louis, Mo.) (10.0 g; 46.05 mmole) was suspended with stirring in thoroughly deoxygenated H2O (200 mL), maintained under an inert gas atmosphere. NaOH (16 g) was added at once and the reaction mixture was heated at ca. 85° C. for 15 min. The reaction was cooled in an ice/salt bath to <5° C., then dropwise treated with a thoroughly deoxygenated solution of citric acid monohydrate (30.63 g) in H2O (30 mL) at a rate that kept the reaction temperature <5° C. NaCl (30 g) was then added and the reaction stirred in the cold for 1 h. The greenish yellow solid product was collected by filtration with suction, washed with a minimum amount of deoxygenated, ice-cold aq 0.5 N citric acid and dried in vacuo overnight to give 3-hydroxyindole (4.94 g; 80%). This product was used without further purification.

후처리

  1. temperaturemaintained under an inert gas atmosphere
  2. temperatureThe reaction was cooled in an ice/salt bath to <5° C.
  3. customthe reaction temperature <5° C
  4. filtrationThe greenish yellow solid product was collected by filtration with suction
  5. washwashed with a minimum amount
  6. customof deoxygenated
  7. dry with materialice-cold aq 0.5 N citric acid and dried in vacuo overnight

출처 및 근거

ORD 기록
ord-f20fb2251740471fa56c039cc9ebbd8a
출처 데이터셋
uspto-grants-2004_08
특허 번호
US06770764B2

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