Iodoethane → 2-Ethyl-2-adamantanol

HRID 1835621

반응식

HRID 1835621 반응식
[Mg].[CH2:2](I)[CH3:3].C([Mg]I)C.[CH:9]12[CH2:18][CH:13]3[CH2:14][CH:15]([CH2:17][CH:11]([CH2:12]3)[C:10]1=[O:19])[CH2:16]2.C12CC3CC(CC(C3)C1O)C2>CCOCC.O1CCCC1>[CH2:11]([C:10]1([OH:19])[CH:9]2[CH2:16][CH:15]3[CH2:14][CH:13]([CH2:2][CH:3]1[CH2:17]3)[CH2:18]2)[CH3:12]

참가 물질

8

반응물 5

HCID 6340IodoethaneHCID 641492-AdamantanolHCID 64151AdamantanoneHCID 5462224MagnesiumHCID 178461634HCID 178461634, 화합물

생성물 1

HCID 44019512-Ethyl-2-adamantanol

시약·촉매·용매 2

HCID 3283Diethyl Ether용매2회HCID 8028Tetrahydrofuran용매

실험 절차

To 5 mL of ether was added 3.7 g (0.15 gram atom) of magnesium. To the mixture was added dropwise a solution of ethyl iodide (30 g, 0.19 mol) in ether (30 mL). The solution of ethylmagnesium iodide thus prepared was added dropwise to a solution of 2-adamantanone (20 g, 0.13 mol) in tetrahydrofuran (100 ml), and the mixture was stirred at room temperature overnight. GC analysis indicated that reduction products, i.e., 2-adamantanol and 2-ethyl-2-adamantanol were formed in 75% and 25%, respectively.

출처 및 근거

ORD 기록
ord-49046d439a0b4ff3b66b3de2c2459af8
출처 데이터셋
uspto-grants-2004_08
특허 번호
US06770777B2

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