p-Anisoyl chloride → 4-[3-(4-Methoxybenzamidyl)benzoyl]-1-methylpiperidine

반응식

[NH2:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][CH:16]=1)[C:5]([CH:7]1[CH2:12][CH2:11][N:10]([CH3:13])[CH2:9][CH2:8]1)=[O:6].[CH3:17][O:18][C:19]1[CH:27]=[CH:26][C:22]([C:23](Cl)=[O:24])=[CH:21][CH:20]=1>>[CH3:17][O:18][C:19]1[CH:27]=[CH:26][C:22]([C:23]([NH:1][C:2]2[CH:3]=[C:4]([CH:14]=[CH:15][CH:16]=2)[C:5]([CH:7]2[CH2:8][CH2:9][N:10]([CH3:13])[CH2:11][CH2:12]2)=[O:6])=[O:24])=[CH:21][CH:20]=1

참가 물질

반응물 2

HCID 7477p-Anisoyl chloride

HCID 101306514-[3-Aminobenzoyl]-1-methylpiperidine

생성물 1

HCID 693559394-[3-(4-Methoxybenzamidyl)benzoyl]-1-methylpiperidine수율 101%

실험 절차

Beginning with 4-[3-aminobenzoyl]-1-methylpiperidine (50 mg, 0.229 mmol) and 4-methoxybenzoyl chloride (117 mg, 0.687 mmol), 81.5 mg (>100%) of the title compound were recovered.

출처 및 근거

ORD 기록: ord-3bbd9b55fcc74e9bb71a40b47079e22a
출처 데이터셋: uspto-grants-2004_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06777428B1

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