Sodium Hydroxide → HCID 23499547, 화합물

HRID 1836424노트

반응식

HRID 1836424 반응식
[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:6]([C:7]([O:9]C)=[O:8])=[C:5]([C:13]2[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=2)[CH:4]=1.[OH-].[Na+]>CO>[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:6]([C:7]([OH:9])=[O:8])=[C:5]([C:13]2[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=2)[CH:4]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 23499548Methyl 4-methoxy-2-(4-fluorophenyl)benzoate

생성물 1

HCID 23499547HCID 23499547, 화합물수율 83%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of methyl 4-methoxy-2-(4-fluorophenyl)benzoate (9.8 g.) in methanol (75 ml.) was added 2N aqueous sodium hydroxide solution (45 ml.) and the mixture heated at reflux for 1.5 hours. The reaction was cooled to ambient temperature, filtered and the filtrate concentrated to remove the methanol. The residual aqueous phase was washed with ether, acidified to pH 1 using concentrated hydrochloric acid and extracted with ethyl acetate. The organic extracts were dried and the solvent removed to give 4-methoxy-2-(4-fluorophenyl)benzoic acid (Compound (xxix) in Scheme 3) as a white solid (7.7 g), which was used without further purification.

후처리

  1. temperaturethe mixture heated
  2. temperatureat reflux for 1.5 hours
  3. filtrationfiltered
  4. concentrationthe filtrate concentrated
  5. customto remove the methanol
  6. washThe residual aqueous phase was washed with ether
  7. extractionextracted with ethyl acetate
  8. customThe organic extracts were dried
  9. customthe solvent removed

출처 및 근거

ORD 기록
ord-c1fd8b72a35a49d0b0f73706736bb79f
출처 데이터셋
uspto-grants-2004_08
특허 번호
US06777438B2

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