Ethyl (4-{3-[(4-fluorophenyl)sulphonyl]-4-hydroxybenzyl}-3,5-dimethylphenoxy)acetate → (4-{3-[(4-Fluorophenyl)sulphonyl]-4-hydroxybenzyl}-3,5-dimethylphenoxy)acetic acid

HRID 1836559노트

반응식

HRID 1836559 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([C:11]2[CH:12]=[C:13]([CH:30]=[CH:31][C:32]=2[OH:33])[CH2:14][C:15]2[C:27]([CH3:28])=[CH:26][C:18]([O:19][CH2:20][C:21]([O:23]CC)=[O:22])=[CH:17][C:16]=2[CH3:29])(=[O:10])=[O:9])=[CH:4][CH:3]=1>C(O)C.[OH-].[Na+]>[F:1][C:2]1[CH:3]=[CH:4][C:5]([S:8]([C:11]2[CH:12]=[C:13]([CH:30]=[CH:31][C:32]=2[OH:33])[CH2:14][C:15]2[C:27]([CH3:28])=[CH:26][C:18]([O:19][CH2:20][C:21]([OH:23])=[O:22])=[CH:17][C:16]=2[CH3:29])(=[O:10])=[O:9])=[CH:6][CH:7]=1

참가 물질

4

반응물 1

HCID 86588309Ethyl (4-{3-[(4-fluorophenyl)sulphonyl]-4-hydroxybenzyl}-3,5-dimethylphenoxy)acetate

생성물 1

HCID 9803511(4-{3-[(4-Fluorophenyl)sulphonyl]-4-hydroxybenzyl}-3,5-dimethylphenoxy)acetic acid

시약·촉매·용매 2

HCID 14798Sodium Hydroxide촉매HCID 702Ethanol용매

실험 절차

37 mg (0.08 mmol) of ethyl (4-{3-[(4-fluorophenyl)sulphonyl]-4-hydroxybenzyl}-3,5-dimethylphenoxy)acetate (Example 1) are dissolved in 1 ml of ethanol, and a few drops of 1 N aqueous sodium hydroxide solution are added. The mixture is stirred at room temperature for thirty minutes and the solvent is then removed under reduced pressure. Water is added to the residue, and the mixture is extracted three times with ethyl acetate. The combined organic phases are dried with sodium sulphate and concentrated. This gives 32 mg (90% of theory) of (4-{3-[(4-fluorophenyl)sulphonyl]-4-hydroxybenzyl}-3,5-dimethylphenoxy)acetic acid.

후처리

  1. customthe solvent is then removed under reduced pressure
  2. additionWater is added to the residue
  3. extractionthe mixture is extracted three times with ethyl acetate
  4. dry with materialThe combined organic phases are dried with sodium sulphate
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-17fe19d775f84c98ac3cd31597ce7ec0
출처 데이터셋
uspto-grants-2004_08
특허 번호
US06777442B2

반응 노트

불러오는 중…