Sodium borohydride → HCID 15858642, 화합물

HRID 1837234노트

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HRID 1837234 반응식
[F:1][C@H:2]1[CH2:19][C@@:17]2([CH3:18])[C@@H:13]([CH2:14][CH2:15][C:16]2=[O:20])[C@H:12]2[C@H:3]1[C:4]1[CH:5]=[CH:6][C:7]([OH:28])=[CH:8][C:9]=1[CH2:10][C@H:11]2[CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][NH:26][CH3:27].[BH4-].[Na+]>CO>[F:1][C@H:2]1[CH2:19][C@@:17]2([CH3:18])[C@@H:13]([CH2:14][CH2:15][C@@H:16]2[OH:20])[C@H:12]2[C@H:3]1[C:4]1[CH:5]=[CH:6][C:7]([OH:28])=[CH:8][C:9]=1[CH2:10][C@H:11]2[CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][NH:26][CH3:27]

참가 물질

4

반응물 2

HCID 4311764Sodium borohydrideHCID 1587066511beta-Fluoro-3-hydroxy-7alpha-[5-(methylamino)-pentyl]-estra-1,3,5(10)-trien-17-one

생성물 1

HCID 15858642HCID 15858642, 화합물수율 61%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

880 mg of 11β-fluoro-3-hydroxy-7α-(5-(methyl-amino)-pentyl)-estra-1,3,5(10)-trien-17-one is dissolved in 15 ml of methanol, mixed in portions with 252 mg of sodium borohydride and stirred for 15 minutes at room temperature. For working-up, the reaction solution is added to saturated common salt solution, extracted several times with methylene chloride, the organic phases are washed with water, dried on magnesium sulfate and concentrated by evaporation in a vacuum. 540 mg of 11β-fluoro-7α-(5-(methyl-amino)-pentyl)-estra-1,3,5(10)-triene-3,17β-diol is obtained as a foam, [α]D=+63° (c=0.5 in chloroform).

후처리

  1. additionthe reaction solution is added to saturated common salt solution
  2. extractionextracted several times with methylene chloride
  3. washthe organic phases are washed with water
  4. customdried on magnesium sulfate
  5. concentrationconcentrated by evaporation in a vacuum

출처 및 근거

ORD 기록
ord-d165227c4f6f4cc6a005d655891f9466
출처 데이터셋
uspto-grants-2004_08
특허 번호
US06780855B2

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