Diethyl (2-methyl-3-hydroxy-4-hydroxymethyl-5-pyridylmethyl)malonate → HCID 9813750, 화합물
반응식
[CH3:1][C:2]1[C:7]([OH:8])=[C:6]([CH2:9][OH:10])[C:5]([CH2:11][CH:12]([C:18]([O:20]CC)=[O:19])[C:13]([O:15]CC)=[O:14])=[CH:4][N:3]=1>[OH-].[Na+].C(O)C>[CH3:1][C:2]1[C:7]([OH:8])=[C:6]([CH2:9][OH:10])[C:5]([CH2:11][CH:12]([C:18]([OH:20])=[O:19])[C:13]([OH:15])=[O:14])=[CH:4][N:3]=1참가 물질
4
실험 절차
The product of Example 25, of structure XXIX (620 mg, 2.0 mmol) was dissolved in aqueous NaOH (2 M, 4 mL) and stirred at room temperature for 1 hour. The reaction was quenched by adding 6 N HCl to give pH 4 to 5. The solution was diluted with 95% ethanol, separated from the precipitated salts and evaporated to give 540 mg.
후처리
- customThe reaction was quenched
- additionby adding 6 N HCl
- customto give pH 4 to 5
- customseparated from the precipitated salts
- customevaporated
- customto give 540 mg
출처 및 근거
- ORD 기록
- ord-48b65dfee79744ed82a2984a1f45076d
- 출처 데이터셋
- uspto-grants-2004_08
- 특허 번호
- US06780997B2
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