Sodium Hydroxide → 4-Amino-3-chloro-6-(3,4-dimethylphenyl)-pyridine-2-carboxylic acid

HRID 1837457노트

반응식

HRID 1837457 반응식
[NH2:1][C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([CH3:14])=[C:10]([CH3:15])[CH:9]=2)[N:5]=[C:4]([C:16]([O:18]C)=[O:17])[C:3]=1[Cl:20].[OH-].[Na+]>CO>[NH2:1][C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([CH3:14])=[C:10]([CH3:15])[CH:9]=2)[N:5]=[C:4]([C:16]([OH:18])=[O:17])[C:3]=1[Cl:20]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 22677522Methyl 4-amino-3-chloro-6-(3,4-dimethylphenyl)pyridine-2-carboxylate

생성물 1

HCID 226773054-Amino-3-chloro-6-(3,4-dimethylphenyl)-pyridine-2-carboxylic acid수율 100%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Methyl 4-amino-3-chloro-6-(3,4-dimethylphenyl)pyridine-2-carboxlate (0.9 g, 0.003 mol) was heated at reflux in methanol (50 mL) and 1N sodium hydroxide (75 mL) for two hours. The reaction mixture was partially concentrated and then acidified with concentrated hydrochloric acid. The solid was collected and dried to give 4-amino-3-chloro-6-(3,4-dimethylphenyl)-pyridine-2-carboxylic acid (0.85 g, 0.003 mol), mp 192-4° C.

후처리

  1. concentrationThe reaction mixture was partially concentrated
  2. customThe solid was collected
  3. customdried

출처 및 근거

ORD 기록
ord-be64961cd2634ce8a8040f6af51430eb
출처 데이터셋
uspto-grants-2004_08
특허 번호
US06784137B2

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